Understanding BMI, Physical Activity, and Dementia Progression
Dementia affects more than 5 million Americans aged 65 and older, with this number expected to triple by 2050. Growing evidence suggests that cardiovascular risk factors (such as overweight or obesity, high cholesterol, hypertension, and diabetes) are significant risk factors for dementia. However, the mechanism behind the association between high adiposity and dementia risk remains uncertain. While some studies have shown an association between higher weight or body mass index (BMI) at age 50 and dementia risk, others have observed an inverse relationship in individuals aged 65 and older, termed the 'obesity paradox' in the literature.
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